The 120-minute Columbus: the Lost Voyagewill premiere in the US in October and tells the story of the explorer's attempt in 1502 to discover the westward passage to Asia.
Columbus lost ships in the voyage and was stranded in Jamaica for months. He also had to deal with periods of serious ill-health.
The film uses dramatic reconstruction and interviews with some of the world's most respected historians and experts. It is scheduled to premiere in the US in October.
Lion Television head of history and special projects Bill Locke said Columbuswould be ambitious but accessible.
He said: ' Columbus: the Lost Voyagegoes beyond the standard pages of the history books to bring to life a legendary explorer's cataclysmic but largely forgotten last voyage. Most people think that Columbus ' exploring career ended in 1492 with the 'discovery' of the New World, but it went on and the results were often disastrous.'
Columbus: the Lost Voyageis executive producer by the History Channel's Marc Etkind and by Locke for Lion. It is directed by Anna Thomson and produced by Sophia Roberts.